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Andrew Donehoo
Aspirin
Aspirin is a white crystalline substance made of carbon, hydrogen, and oxygen. It is used
in the treatment of rheumatic fever, headaches, neuralgia, colds, and arthritis; reduce
temperature and pain. The formula for aspirin is CH3CO2C6H4CO2H. Aspirin's scientific name
is actylsalicylic acid (ASA). The main ingredient in ASA is salicylic acid. This
ingredient grows in small roots, leaves, flowers and fruits on plants.
About 100 years ago, a German chemist, Felix Hoffmann, set out to find a drug that would
ease his father's arthritis without causing severe stomach irritation that came from
sodium salicylate, the standard anti-arthritis treatment of the time. Hoffmann figured
that the acidity of the salicylate made it hard on the stomach's lining. He began looking
for a less acidic formulation. His search led him to the synthesization of acetylsalicylic
acid. The compound shared the therapeutic properties of other salicylates, but caused less
stomach irritation. ASA reduced fever, relieved moderate pain, and, at higher doses,
alleviated rheumatic fever and arthritic conditions.
Though Hoffmann was confident that ASA would prove more affective than other salicylates,
but his superiors incorrectly stated that ASA weakens the heart and that physicians would
not subscribe it. Hoffmann's employer, Friedrich Bayer and Company, gave ASA its now
famous name, aspirin.
It is not yet fully known how aspirin works, but most authorities agree
that it achieves some of its effects by hindering the flow of prostaglandins.
Prostaglandins are hormone-like substances that influence the elasticity of blood vessels.
John Vane, Ph. D., noted that many forms of tissue injury were followed by the release of
prostaglandins. It was proved that prostaglndins caused redness and fever, common signs of
inflammation. Vane's research showed that by blocking the flow of prostaglandins, aspirin
prevented blood from aggregating and forming blood clots.
Aspirin can be used for the temporary relief of headaches, painful
discomfort and fever from colds, muscular aches and pains, and temporary relief to minor
pains of arthritis, toothaches, and menstrual pain. Aspirin should not be used in patients
who have an allergic reaction to aspirin and/or nonsteroidal anti-inflammatory agents.
The usual adult dosage for adults and children over the age of 12 is one or two tablets
with water. This may be repeated every 4 hours as necessary up to 12 tablets a day or as
directed by your doctor. You should not give aspirin to children under the age of 12. An
overdose of 200 to 500 mg/kg is in the fatal range. Early symptoms of overdose are
vomiting, hypernea, hyperactivity, and convulsions. This progresses quickly to depression,
coma, respiratory failure and collapse. In case of an overdose, intensive supportive
therapy should be instituted immediately. Plasma salicylates levels should be measured in
order to determine the severity of the poisoning and to provide a guide for therapy.
Emptying the stomach should be accomplished as soon as possible.
Children and teenagers should not use aspirin for chicken pox or flu symptoms before a
doctor is consulted. You should not take this product if you are allergies to aspirin,
have asthma, stomach problems that reoccur, gastric ulcers or bleeding problems unless
directed by a doctor. Aspirin should be kept out of reach of children. In case of an
overdose, you should seek professional assistance or contact a poison control center
immediately. If you are pregnant or nursing a baby, seek the advice of a health
professional before taking aspirin.
Since the discovery of aspirin, it has been proved to prevent or
protect against recurrent strokes, throat cancer, breast cancer, coon cancer, and reduce
the effects of heart attacks and strokes. A heart attack occurs when the is a blockage of
blood flow to the heart muscle. Without adequate blood supply, the affected area of muscle
dies and the heart's pumping action is either impaired or stopped altogether. When aspirin
is taken, it thins the blood, allowing it to pass trough the thinner than usual blood
vessels. Studies show that people who take an aspirin on a daily basis have a reduced risk
of heart attack or stroke.
Though aspirin is taken for granted, it is a product that over a
process of many years, evolved from willow bark into the acetylsalicylic acid that we take
form symptoms ranging from the common cold to heart attacks.
In the top diagram on the next page, the Kolbe Synthesis is shown. It
shows how salicylic acid is produced. The middle diagram shows the process that turns
salicylic acid into acetylsalicylic acid. In the 3-D model of aspirin, the gray atoms are
carbon, the white atoms are hydrogen, and the red atoms are oxygen.
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